| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRIN1 |
| Gene ID: | 2902 |
| Uniprot ID: | NMDZ1_HUMAN |
| Specificity: | A synthetic phosphorylated peptide around S896 of human NMDAR1 (NP_015566.1). |
| Immunogen Sequence: | RRSSK |
| Post Translational Modifications | NMDA is probably regulated by C-terminal phosphorylation of an isoform of GRIN1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1 Glun1 Glutamate Nmda Receptor Subunit Zeta-1 N-Methyl-D-Aspartate Receptor Subunit Nr1 Nmd-R1 Hnr1 |
| Database Links | Reactome: R-HSA-3928662 Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5673001 Reactome: R-HSA-6794361 Reactome: R-HSA-8849932 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane Postsynaptic Density Membrane Synaptic Cell Membrane Synaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b Subunit Association With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 1 antibody Anti-Glun1 antibody Anti-Glutamate Nmda Receptor Subunit Zeta-1 antibody Anti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibody Anti-Nmd-R1 antibody Anti-Hnr1 antibody Anti-GRIN1 antibody Anti-NMDAR1 antibody |
Information sourced from Uniprot.org