• Immunohistochemistry analysis of paraffin-embedded human brain, using GluR1 (Phospho-Ser849) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-GRIA1-Ser849 antibody (816-865 aa) (STJ91286)

SKU:
STJ91286

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Glutamate receptor 1-Ser849 (816-865 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRIA1
Gene ID: 2890
Uniprot ID: GRIA1_HUMAN
Immunogen Region: 816-865 aa
Specificity: Phospho-GluR-1 (S849) Polyclonal Antibody detects endogenous levels of GluR-1 protein only when phosphorylated at S849.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GluR1 around the phosphorylation site of Ser849 at the amino acid range 816-865
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation.
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Protein Name Glutamate Receptor 1
Glur-1
Ampa-Selective Glutamate Receptor 1
Glur-A
Glur-K1
Glutamate Receptor Ionotropic - Ampa 1
Glua1
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-399710
Reactome: R-HSA-399719
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-5694530
Reactome: R-HSA-8849932
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Cell Membrane
Postsynaptic Density Membrane
Cell Projection
Dendrite
Dendritic Spine
Early Endosome Membrane
Recycling Endosome Membrane
Presynapse
Synapse
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Colocalizes With Pdlim4 In Early Endosomes
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Localized To Cone Photoreceptor Pedicles
Alternative Antibody Names Anti-Glutamate Receptor 1 antibody
Anti-Glur-1 antibody
Anti-Ampa-Selective Glutamate Receptor 1 antibody
Anti-Glur-A antibody
Anti-Glur-K1 antibody
Anti-Glutamate Receptor Ionotropic - Ampa 1 antibody
Anti-Glua1 antibody
Anti-GRIA1 antibody
Anti-GLUH1 antibody
Anti-GLUR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance