| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-GRB2-associated-binding protein 2-Tyr614 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GAB2 |
| Gene ID: | 9846 |
| Uniprot ID: | GAB2_HUMAN |
| Specificity: | This antibody detects endogenous levels of GAB2 (Phospho Tyr614) Rabbit pAb at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human GAB2 (Phospho Tyr614) |
| Post Translational Modifications | Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL. Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. Dephosphorylated by PTPN11. |
| Function | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Protein Name | Grb2-Associated-Binding Protein 2Grb2-Associated Binder 2Growth Factor Receptor Bound Protein 2-Associated Protein 2Pp100 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-1839117Reactome: R-HSA-2219530Reactome: R-HSA-2730905Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-8983432Reactome: R-HSA-912526Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703465Reactome: R-HSA-9703648 |
| Cellular Localisation | CytoplasmCell MembraneMembrane Raft |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 2 antibodyAnti-Grb2-Associated Binder 2 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibodyAnti-Pp100 antibodyAnti-GAB2 antibodyAnti-KIAA0571 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
