| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-FHOD1-Thr-1141 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FHOD1 |
| Gene ID: | 29109 |
| Uniprot ID: | FHOD1_HUMAN |
| Specificity: | This antibody was cross-adsorbed to unphosphorylated FHOD1 (Thr-1141) peptide before affinity purification using phospho-FHOD1 (Thr-1141) peptide (without carrier). The antibody detects a 140 kDa* protein corresponding to the apparent molecular mass |
| Immunogen: | Phospho-FHOD1 (Thr-1141) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Thr-1141 in human FHOD1. This peptide sequence is highly conserved in rat and mouse FHOD1, and is well conserved in FHOD3 (Thr-1399). |
| Tissue Specificity | Ubiquitous. Highly expressed in spleen. |
| Post Translational Modifications | Phosphorylated by ROCK1. |
| Function | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. |
| Protein Name | Fh1/Fh2 Domain-Containing Protein 1Formin Homolog Overexpressed In Spleen 1FhosFormin Homology 2 Domain-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionBlebPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Fh1/Fh2 Domain-Containing Protein 1 antibodyAnti-Formin Homolog Overexpressed In Spleen 1 antibodyAnti-Fhos antibodyAnti-Formin Homology 2 Domain-Containing Protein 1 antibodyAnti-FHOD1 antibodyAnti-FHOS antibodyAnti-FHOS1 antibody |
Information sourced from Uniprot.org