| Post Translational Modifications | Autocleaves. This function, which is not essential for its protease activity, is unknown. Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation. |
| Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
| Protein Name | SeparinCaspase-Like Protein Espl1Extra Spindle Poles-Like 1 ProteinSeparase |
| Database Links | Reactome: R-HSA-2467813 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Separin antibodyAnti-Caspase-Like Protein Espl1 antibodyAnti-Extra Spindle Poles-Like 1 Protein antibodyAnti-Separase antibodyAnti-ESPL1 antibodyAnti-ESP1 antibodyAnti-KIAA0165 antibody |
Information sourced from Uniprot.org
