Anti-Phospho-EPHB1-Tyr600/602/614/596 antibody (STJA0009974)

SKU:
STJA0009974

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Ephrin type-B receptor 1-Tyr600/602/614/596 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHB1
Gene ID: 2047
Uniprot ID: EPHB1_HUMAN
Specificity: This antibody detects endogenous levels of EPHB1/2/3/4 (Phospho-Tyr600/602/614/596) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)
Tissue Specificity Preferentially expressed in brain.
Post Translational Modifications Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. Ubiquitinated.(EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
Protein Name Ephrin Type-B Receptor 1
Elk
Eph Tyrosine Kinase 2
Eph-Like Kinase 6
Ek6
Hek6
Neuronally-Expressed Eph-Related Tyrosine Kinase
Net
Tyrosine-Protein Kinase Receptor Eph-2
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Cell Projection
Dendrite
Alternative Antibody Names Anti-Ephrin Type-B Receptor 1 antibody
Anti-Elk antibody
Anti-Eph Tyrosine Kinase 2 antibody
Anti-Eph-Like Kinase 6 antibody
Anti-Ek6 antibody
Anti-Hek6 antibody
Anti-Neuronally-Expressed Eph-Related Tyrosine Kinase antibody
Anti-Net antibody
Anti-Tyrosine-Protein Kinase Receptor Eph-2 antibody
Anti-EPHB1 antibody
Anti-ELK antibody
Anti-EPHT2 antibody
Anti-HEK6 antibody
Anti-NET antibody

Information sourced from Uniprot.org

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