| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Protein 4.1-Tyr660 (626-675 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPB41 |
| Gene ID: | 2035 |
| Uniprot ID: | EPB41_HUMAN |
| Immunogen Region: | 626-675 aa |
| Specificity: | Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human EPB41 around the phosphorylation site of Tyr660/418 at the amino acid range 626-675 |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. |
| Protein Name | Protein 4.1P4.14.1rBand 4.1Epb4.1Erythrocyte Membrane Protein Band 4.1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexNucleus |
| Alternative Antibody Names | Anti-Protein 4.1 antibodyAnti-P4.1 antibodyAnti-4.1r antibodyAnti-Band 4.1 antibodyAnti-Epb4.1 antibodyAnti-Erythrocyte Membrane Protein Band 4.1 antibodyAnti-EPB41 antibodyAnti-E41P antibody |
Information sourced from Uniprot.org