| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Eukaryotic translation initiation factor 4B-Ser422 (388-437 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF4B |
| Gene ID: | 1975 |
| Uniprot ID: | IF4B_HUMAN |
| Immunogen Region: | 388-437 aa |
| Specificity: | Phospho-eIF4B (S422) Polyclonal Antibody detects endogenous levels of eIF4B protein only when phosphorylated at S422. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human eIF4B around the phosphorylation site of Ser422 at the amino acid range 388-437 |
| Function | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| Protein Name | Eukaryotic Translation Initiation Factor 4b Eif-4b |
| Database Links | Reactome: R-HSA-156827 Reactome: R-HSA-166208 Reactome: R-HSA-429947 Reactome: R-HSA-72649 Reactome: R-HSA-72662 Reactome: R-HSA-72702 Reactome: R-HSA-72706 Reactome: R-HSA-9820841 Reactome: R-HSA-9820865 |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4b antibody Anti-Eif-4b antibody Anti-EIF4B antibody |
Information sourced from Uniprot.org