Anti-Phospho-EIF2S2-Ser67 antibody (STJA0009866)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human eIF2B (Phospho Ser67)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Eukaryotic translation initiation factor 2 subunit 2-Ser67 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF2S2 |
| Gene ID | 8894 |
| Uniprot ID | IF2B_HUMAN |
| Immunogen | Synthesized peptide derived from human eIF2B (Phospho Ser67) |
| Specificity | This antibody detects endogenous levels of Human eIF2B (Phospho Ser67) |
Additional Info
| Function | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. |
| Protein Name | Eukaryotic Translation Initiation Factor 2 Subunit 2Eukaryotic Translation Initiation Factor 2 Subunit BetaEif2-Beta |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-381042Reactome: R-HSA-382556Reactome: R-HSA-72649Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-72731Reactome: R-HSA-9633012Reactome: R-HSA-9648895Reactome: R-HSA-9833482Reactome: R-HSA-9840373 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 2 Subunit 2 antibodyAnti-Eukaryotic Translation Initiation Factor 2 Subunit Beta antibodyAnti-Eif2-Beta antibodyAnti-EIF2S2 antibodyAnti-EIF2B antibody |
Information sourced from Uniprot.org