Anti-Phospho-DOK2-Tyr351 antibody (STJ196370)

SKU:
STJ196370
$64.80 - $340.20
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Docking protein 2-Tyr351 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK2
Gene ID: 9046
Uniprot ID: DOK2_HUMAN
Specificity: This antibody detects endogenous levels of Human p56Dok-2 (phospho-Tyr351)
Immunogen: Synthesized phosho peptide around human p56Dok-2 (Tyr351)
Post Translational Modifications On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Protein Name Docking Protein 2
Downstream Of Tyrosine Kinase 2
P56(Dok-2
Database Links Reactome: R-HSA-210993
Reactome: R-HSA-8853659
Alternative Antibody Names Anti-Docking Protein 2 antibody
Anti-Downstream Of Tyrosine Kinase 2 antibody
Anti-P56(Dok-2 antibody
Anti-DOK2 antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ11105773 Anti-Phospho-DOK2-Y299 antibody (STJ11105773) Rabbit Polyclonal Human WB/IF/ICC
STJ91275 Anti-Phospho-DOK2-Tyr345 antibody (STJ91275) Rabbit Polyclonal Human/Mouse IHC/IF/ELISA
STJA0010029 Anti-Phospho-DOK2-Tyr139 antibody (STJA0010029) Rabbit Polyclonal Human/Mouse IHC/WB
STJ90245 Anti-Phospho-DOK2-Tyr299 antibody (266-315 aa) (STJ90245) Rabbit Polyclonal Human/Mouse/Monkey WB/IF/ELISA
STJ116019 Anti-DOK2 antibody (1-260) (STJ116019) Rabbit Polyclonal Human/Mouse WB/ELISA
!