Anti-Phospho-CREB1-Ser142 antibody (111-160 aa) (STJ91016)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CREB around the phosphorylation site of Ser142 at the amino acid range 111-160
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Cyclic AMP-responsive element-binding protein 1-Ser142 (111-160 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CREB1 |
| Gene ID | 1385 |
| Uniprot ID | CREB1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CREB around the phosphorylation site of Ser142 at the amino acid range 111-160 |
| Immunogen Region | 111-160 aa |
| Specificity | Phospho-CREB-1 (S142) Polyclonal Antibody detects endogenous levels of CREB-1 protein only when phosphorylated at S142. |
Additional Info
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 1Creb-1Camp-Responsive Element-Binding Protein 1 |
| Database Links | Reactome: R-HSA-111931 P16220-1Reactome: R-HSA-111932 P16220-1Reactome: R-HSA-198693 P16220-1Reactome: R-HSA-199920 P16220-1Reactome: R-HSA-2151201 P16220-1Reactome: R-HSA-2197563 P16220-1Reactome: R-HSA-375165 P16220-1Reactome: R-HSA-400253 P16220-1Reactome: R-HSA-442720 P16220-1Reactome: R-HSA-442729 P16220-1Reactome: R-HSA-442742 P16220-1Reactome: R-HSA-5674400 P16220-1Reactome: R-HSA-881907 P16220-1Reactome: R-HSA-9022692 P16220-1Reactome: R-HSA-9022699 P16220-1Reactome: R-HSA-9022702 P16220-1Reactome: R-HSA-9022707 P16220-1Reactome: R-HSA-9031628 P16220-1Reactome: R-HSA-9609690 P16220-1Reactome: R-HSA-9616222 P16220-1Reactome: R-HSA-9634638 P16220-1Reactome: R-HSA-9660821 P16220-1Reactome: R-HSA-9664323 P16220-1Reactome: R-HSA-9707616 P16220-1Reactome: R-HSA-9824585 P16220-1Reactome: R-HSA-9856649 P16220-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 1 antibodyAnti-Creb-1 antibodyAnti-Camp-Responsive Element-Binding Protein 1 antibodyAnti-CREB1 antibody |
Information sourced from Uniprot.org