| Host: | Rabbit |
| Applications: | WB/IF/ICC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:100-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK6 |
| Gene ID: | 1021 |
| Uniprot ID: | CDK6_HUMAN |
| Specificity: | A phospho specific peptide corresponding to residues surrounding Y24 of human CDK6 |
| Tissue Specificity | Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. |
| Post Translational Modifications | Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity. |
| Function | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation.promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation.prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases. |
| Protein Name | Cyclin-Dependent Kinase 6 Cell Division Protein Kinase 6 Serine/Threonine-Protein Kinase Plstire |
| Database Links | Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2559585 Reactome: R-HSA-69231 Reactome: R-HSA-8934593 Reactome: R-HSA-9630794 Reactome: R-HSA-9632700 Reactome: R-HSA-9661069 Reactome: R-HSA-9754119 |
| Cellular Localisation | Cytoplasm Nucleus Cell Projection Ruffle Cytoskeleton Microtubule Organizing Center Centrosome Localized To The Ruffling Edge Of Spreading Fibroblasts Kinase Activity Only In Nucleus Localized To The Cytosol Of Neurons And Showed Prominent Staining Around Either Side Of The Nucleus Present In The Cytosol And In The Nucleus In Interphase Cells And At The Centrosome During Mitosis From Prophase To Telophase |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 6 antibody Anti-Cell Division Protein Kinase 6 antibody Anti-Serine/Threonine-Protein Kinase Plstire antibody Anti-CDK6 antibody Anti-CDKN6 antibody |
Information sourced from Uniprot.org