• Western blot analysis of lysates from K562 cells treated with Na3VO4 0.3nM 40', using BL-CAM (Phospho-Tyr807) Antibody. The lane on the right is blocked with the phospho peptide.

Anti-Phospho-CD22-Tyr807 antibody (776-825 aa) (STJ90608)

SKU:
STJ90608

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-B-cell receptor CD22-Tyr807 (776-825 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD22
Gene ID: 933
Uniprot ID: CD22_HUMAN
Immunogen Region: 776-825 aa
Specificity: Phospho-CD22 (Y807) Polyclonal Antibody detects endogenous levels of CD22 protein only when phosphorylated at Y807.
Immunogen: The antiserum was produced against synthesized peptide derived from the human BL-CAM around the phosphorylation site of Tyr807 at the amino acid range 776-825
Post Translational Modifications Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Phosphorylated on tyrosine residues by LYN.
Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins.one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Protein Name B-Cell Receptor Cd22
B-Lymphocyte Cell Adhesion Molecule
Bl-Cam
Sialic Acid-Binding Ig-Like Lectin 2
Siglec-2
T-Cell Surface Antigen Leu-14
Cd Antigen Cd22
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-5690714
Reactome: R-HSA-983695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-B-Cell Receptor Cd22 antibody
Anti-B-Lymphocyte Cell Adhesion Molecule antibody
Anti-Bl-Cam antibody
Anti-Sialic Acid-Binding Ig-Like Lectin 2 antibody
Anti-Siglec-2 antibody
Anti-T-Cell Surface Antigen Leu-14 antibody
Anti-Cd Antigen Cd22 antibody
Anti-CD22 antibody
Anti-SIGLEC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance