| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Calcium/calmodulin-dependent protein kinase kinase 2-Ser511 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAMKK2 |
| Gene ID: | 10645 |
| Uniprot ID: | KKCC2_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human Mouse Rat CaMKK2 (phospho-Ser511) |
| Immunogen: | Synthesized phosho peptide around human CaMKK2 (Ser511) |
| Post Translational Modifications | Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Cam-Kk 2 Cam-Kinase Kinase 2 Camkk 2 Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta Cam-Kk Beta Cam-Kinase Kinase Beta Camkk Beta |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-442729 Reactome: R-HSA-9619229 Reactome: R-HSA-9619483 |
| Cellular Localisation | Nucleus Cytoplasm Cell Projection Neuron Projection Predominantly Nuclear In Unstimulated Cells Relocalizes Into Cytoplasm And Neurites After Forskolin Induction |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 antibody Anti-Cam-Kk 2 antibody Anti-Cam-Kinase Kinase 2 antibody Anti-Camkk 2 antibody Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta antibody Anti-Cam-Kk Beta antibody Anti-Cam-Kinase Kinase Beta antibody Anti-Camkk Beta antibody Anti-CAMKK2 antibody Anti-CAMKKB antibody Anti-KIAA0787 antibody |
Information sourced from Uniprot.org