| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Calcium/calmodulin-dependent protein kinase kinase 1-Ser458/495 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAMKK1 |
| Gene ID: | 84254 |
| Uniprot ID: | KKCC1_HUMAN |
| Specificity: | This antibody detects endogenous levels of CAMKK1/2 (Phospho-Ser458/495) at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human CAMKK1/2 (Phospho-Ser458/495) |
| Post Translational Modifications | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4. |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 Cam-Kk 1 Cam-Kinase Kinase 1 Camkk 1 Cam-Kinase Iv Kinase Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha Cam-Kk Alpha Cam-Kinase Kinase Alpha Camkk Alpha |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-442729 Reactome: R-HSA-9619229 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 antibody Anti-Cam-Kk 1 antibody Anti-Cam-Kinase Kinase 1 antibody Anti-Camkk 1 antibody Anti-Cam-Kinase Iv Kinase antibody Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha antibody Anti-Cam-Kk Alpha antibody Anti-Cam-Kinase Kinase Alpha antibody Anti-Camkk Alpha antibody Anti-CAMKK1 antibody Anti-CAMKKA antibody |
Information sourced from Uniprot.org