| Host: | Rabbit |
| Applications: | FC/ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-CACNB2 (600-655) is suitable for use in Flow Cytometry, ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.6 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Cacnb2 |
| Gene ID: | 116600 |
| Uniprot ID: | CACB2_RAT |
| Immunogen Region: | 600-655 |
| Immunogen: | Synthetic peptide taken within amino acid region 600-655 on rat CACNB2 protein. |
| Tissue Specificity | Highly expressed in heart and brain, and at lower levels in lung. |
| Post Translational Modifications | Regulated through phosphorylation at Thr-549 by CaMK2D. |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 Cab2 Calcium Channel Voltage-Dependent Subunit Beta 2 |
| Database Links | Reactome: R-RNO-112308 Reactome: -RNO-422356 Reactome: -RNO-5576892 Reactome: -RNO-5576893 |
| Cellular Localisation | Cell Membrane Sarcolemma Peripheral Membrane Protein Cytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibody Anti-Cab2 antibody Anti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibody Anti-Cacnb2 antibody Anti-Cacnlb2 antibody |
Information sourced from Uniprot.org