| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Sodium/potassium-transporting ATPase subunit alpha-1/K+ ATPase alpha-1 subunit-Tyr260 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP1A1 |
| Gene ID: | 476 |
| Uniprot ID: | AT1A1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Na+/K+-ATPase Alpha 1 (Phospho-Tyr260). |
| Immunogen: | Synthesized phospho derived from the human Na+/K+-ATPase Alpha 1 (Phospho-Tyr260) Polyclonal |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Alpha-1 Na(+/K(+ Atpase Alpha-1 Subunit Sodium Pump Subunit Alpha-1 |
| Database Links | Reactome: R-HSA-5578775 Reactome: R-HSA-936837 Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Sarcolemma Cell Projection Axon Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Alpha-1 antibody Anti-Na(+/K(+ Atpase Alpha-1 Subunit antibody Anti-Sodium Pump Subunit Alpha-1 antibody Anti-ATP1A1 antibody |
Information sourced from Uniprot.org