| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:100-1:500IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirement |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHGDH |
| Gene ID: | 26227 |
| Uniprot ID: | SERA_HUMAN |
| Immunogen Region: | 264-533 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 264-533 of human PHGDH (NP_006614.2). |
| Immunogen Sequence: | EEPPRDRALVDHENVISCPH LGASTKEAQSRCGEEIAVQF VDMVKGKSLTGVVNAQALTS AFSPHTKPWIGLAEALGTLM RAWAGSPKGTIQVITQGTSL KNAGNCLSPAVIVGLLKEAS KQADVNLVNAKLLVKEAGLN VTTSHSPAAPGEQGFGECLL AVALAGAPYQAVGLVQGTTP VLQGLNGAVFRPEVPLRRDL PLLLFRTQTSDPAMLPTMIG LLAEAGVRLLSYQTSLVSD |
| Function | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. |
| Protein Name | D-3-Phosphoglycerate Dehydrogenase3-Pgdh2-Oxoglutarate ReductaseMalate Dehydrogenase |
| Database Links | Reactome: R-HSA-977347 |
| Alternative Antibody Names | Anti-D-3-Phosphoglycerate Dehydrogenase antibodyAnti-3-Pgdh antibodyAnti-2-Oxoglutarate Reductase antibodyAnti-Malate Dehydrogenase antibodyAnti-PHGDH antibodyAnti-PGDH3 antibody |
Information sourced from Uniprot.org