Anti-PHF13 antibody (206-256 aa) (STJ196026)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PHF13 at the amino acid range 206-256
General Information
| Short Description | Rabbit polyclonal anti-PHD finger protein 13 (206-256 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHF13 |
| Gene ID | 148479 |
| Uniprot ID | PHF13_HUMAN |
| Immunogen | Synthesized peptide derived from the human PHF13 at the amino acid range 206-256 |
| Immunogen Region | 206-256 aa |
| Specificity | This antibody detects endogenous levels of PHF13 at Human/Mouse |
Additional Info
| Function | Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis. |
| Protein Name | Phd Finger Protein 13Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1Spoc1 |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmPredominantly Bound To ChromatinBut A Minor Proportion Is Also Detected In The Nucleoplasm |
| Alternative Antibody Names | Anti-Phd Finger Protein 13 antibodyAnti-Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1 antibodyAnti-Spoc1 antibodyAnti-PHF13 antibody |
Information sourced from Uniprot.org