Anti-PHEX antibody (STJA0009736)

SKU:
STJA0009736
$64.80 - $340.20
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phosphate-regulating neutral endopeptidase PHEX is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PHEX
Gene ID: 5251
Uniprot ID: PHEX_HUMAN
Specificity: This antibody detects endogenous levels of PHEX at Human, Mouse
Immunogen: Synthesized peptide derived from human PHEX
Function Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
Protein Name Phosphate-Regulating Neutral Endopeptidase Phex
Metalloendopeptidase Homolog Pex
Vitamin D-Resistant Hypophosphatemic Rickets Protein
X-Linked Hypophosphatemia Protein
Hyp
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Phosphate-Regulating Neutral Endopeptidase Phex antibody
Anti-Metalloendopeptidase Homolog Pex antibody
Anti-Vitamin D-Resistant Hypophosphatemic Rickets Protein antibody
Anti-X-Linked Hypophosphatemia Protein antibody
Anti-Hyp antibody
Anti-PHEX antibody
Anti-PEX antibody

Information sourced from Uniprot.org

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