Anti-PHEX antibody (520-749 aa) (STJ11107479)

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STJ11107479
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: PHEX
Gene ID: 5251
Uniprot ID: PHEX_HUMAN
Immunogen Region: 520-749 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 520-749 of human PHEX (NP_000435.3).
Immunogen Sequence: WLRKAVPKTEWFTNPTTVNA FYSASTNQIRFPAGELQKPF FWGTEYPRSLSYGAIGVIVG HEFTHGFDNNGRKYDKNGNL DPWWSTESEEKFKEKTKCMI NQYSNYYWKKAGLNVKGKRT LGENIADNGGLREAFRAYRK WINDRRQGLEEPLLPGITFT NNQLFFLSYAHVRCNSYRPE AAREQVQIGAHSPPQFRVNG AISNFEEFQKAFNCPPNSTM NRGMDSCRLW
Tissue Specificity Specifically expressed in ovary. Expressed at low levels in kidney.
Function Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
Protein Name Phosphate-Regulating Neutral Endopeptidase Phex
Metalloendopeptidase Homolog Pex
Vitamin D-Resistant Hypophosphatemic Rickets Protein
X-Linked Hypophosphatemia Protein
Hyp
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Phosphate-Regulating Neutral Endopeptidase Phex antibody
Anti-Metalloendopeptidase Homolog Pex antibody
Anti-Vitamin D-Resistant Hypophosphatemic Rickets Protein antibody
Anti-X-Linked Hypophosphatemia Protein antibody
Anti-Hyp antibody
Anti-PHEX antibody
Anti-PEX antibody

Information sourced from Uniprot.org

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