Anti-PHC1 antibody (750-940) (STJ28406)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PHC1 (750-940) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PHC1 |
| Gene ID | 1911 |
| Uniprot ID | PHC1_HUMAN |
| Immunogen Region | 750-940 |
| Immunogen Sequence | FPVGCSQLLKESEKPLQTGL PTGLTENQSGGPLGVDSPSA ELDKKANLLKCEYCGKYAPA EQFRGSKRFCSMTCAKRYNV SCSHQFRLKRKKMKEFQEAN YARVRRRGPRRSSSDIARAK IQGKCHRGQEDSSRGSDNSS YDEALSPTSPGPLSVRAGHG ERDLGNPNTAPPTPELHGIN PVFLSSNPSRW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 750-940 of human PHC1 (NP_004417.2). |
Additional Info
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. |
| Protein Name | Polyhomeotic-Like Protein 1Hph1Early Development Regulatory Protein 1 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polyhomeotic-Like Protein 1 antibodyAnti-Hph1 antibodyAnti-Early Development Regulatory Protein 1 antibodyAnti-PHC1 antibodyAnti-EDR1 antibodyAnti-PH1 antibody |
Information sourced from Uniprot.org