| Host: |
Goat |
| Applications: |
Pep-ELISA/IF/FC |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Goat polyclonal antibody anti-PGRMC2 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:1000.IF: Strong expression of the protein seen in the cytoplasm and plasma membranes of HeLa cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of HeLa cells. Recommended c |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PGRMC2 |
| Gene ID: |
10424 |
| Uniprot ID: |
PGRC2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006311.3 |
| Immunogen Sequence: |
DEEDTKDHNKQD |
| Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 2Progesterone Membrane-Binding ProteinSteroid Receptor Protein Dg6 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinNucleus EnvelopeEndoplasmic ReticulumSecreted |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 2 antibodyAnti-Progesterone Membrane-Binding Protein antibodyAnti-Steroid Receptor Protein Dg6 antibodyAnti-PGRMC2 antibodyAnti-DG6 antibodyAnti-PMBP antibody |
Information sourced from Uniprot.org
