| Tissue Specificity | Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men. |
| Post Translational Modifications | Phosphorylated at Ser-203 by MAPK1/ERK2 under hypoxic conditions, which promotes its mitochondrial targeting. |
| Function | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility. |
| Protein Name | Phosphoglycerate Kinase 1Cell Migration-Inducing Gene 10 ProteinPrimer Recognition Protein 2Prp 2 |
| Database Links | Reactome: R-HSA-70171Reactome: R-HSA-70263Reactome: R-HSA-9636667 |
| Cellular Localisation | CytoplasmCytosolMitochondrion MatrixHypoxic Conditions Promote Mitochondrial TargetingTargeted To The Mitochondrion Following Phosphorylation By Mapk1/Erk2Cis-Trans Isomerization By Pin1And Binding To Mitochondrial Circrna Mcpgk1 |
| Alternative Antibody Names | Anti-Phosphoglycerate Kinase 1 antibodyAnti-Cell Migration-Inducing Gene 10 Protein antibodyAnti-Primer Recognition Protein 2 antibodyAnti-Prp 2 antibodyAnti-PGK1 antibodyAnti-PGKA antibodyAnti-MIG10 antibodyAnti-OK antibodyAnti-SW-cl.110 antibody |
Information sourced from Uniprot.org
