| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/threonine-protein phosphatase PGAM5, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PGAM5 |
| Gene ID: |
192111 |
| Uniprot ID: |
PGAM5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PGAM5 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PGAM5 |
| Function | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2. Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria. |
| Protein Name | Serine/Threonine-Protein Phosphatase Pgam5 - MitochondrialBcl-Xl-Binding Protein V68Phosphoglycerate Mutase Family Member 5 |
| Database Links | Reactome: R-HSA-8934903 Q96HS1-2Reactome: R-HSA-9861718 Q96HS1-1 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinMitochondrion Inner MembraneIsoform 2 Overexpression Results In The Formation Of Disconnected Punctuate Mitochondria Distributed Throughout The CytoplasmIsoform 1 Overexpression Results In The Clustering Of Mitochondria Around The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase Pgam5 - Mitochondrial antibodyAnti-Bcl-Xl-Binding Protein V68 antibodyAnti-Phosphoglycerate Mutase Family Member 5 antibodyAnti-PGAM5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
