| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/threonine-protein phosphatase PGAM5, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PGAM5 |
| Gene ID: |
192111 |
| Uniprot ID: |
PGAM5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PGAM5 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PGAM5 |
| Function | Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. |
| Protein Name | Serine/Threonine-Protein Phosphatase Pgam5 - MitochondrialBcl-Xl-Binding Protein V68Phosphoglycerate Mutase Family Member 5 |
| Database Links | Reactome: R-HSA-8934903 Q96HS1-2 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinMitochondrion Inner MembraneIsoform 2 Overexpression Results In The Formation Of Disconnected Punctuate Mitochondria Distributed Throughout The CytoplasmIsoform 1 Overexpression Results In The Clustering Of Mitochondria Around The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase Pgam5 - Mitochondrial antibodyAnti-Bcl-Xl-Binding Protein V68 antibodyAnti-Phosphoglycerate Mutase Family Member 5 antibodyAnti-PGAM5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
