| Short Description : | Rabbit polyclonal PGAM1 (1-254) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PGAM1 |
| Gene ID: | 5223 |
| Uniprot ID: | PGAM1_HUMAN |
| Immunogen Region: | 1-254 |
| Immunogen Sequence: | MAAYKLVLIRHGESAWNLEN RFSGWYDADLSPAGHEEAKR GGQALRDAGYEFDICFTSVQ KRAIRTLWTVLDAIDQMWLP VVRTWRLNERHYGGLTGLNK AETAAKHGEAQVKIWRRSYD VPPPPMEPDHPFYSNISKDR RYADLTEDQLPSCESLKDTI ARALPFWNEEIVPQIKEGKR VLIAAHGNSLRGIVKHLEGL SEEAIMELNLPTGIPIVYEL DKNLKPIKPMQFLGDEETV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-254 of human PGAM1 (NP_002620.1). |
| Tissue Specificity | Expressed in the liver and brain. Not found in the muscle. |
| Post Translational Modifications | Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme. |
| Function | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate. |
| Protein Name | Phosphoglycerate Mutase 1Bpg-Dependent Pgam 1Phosphoglycerate Mutase Isozyme BPgam-B |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-70171Reactome: R-HSA-70263 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Phosphoglycerate Mutase 1 antibodyAnti-Bpg-Dependent Pgam 1 antibodyAnti-Phosphoglycerate Mutase Isozyme B antibodyAnti-Pgam-B antibodyAnti-PGAM1 antibodyAnti-PGAMA antibodyAnti-CDABP0006 antibody |
Information sourced from Uniprot.org
