| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PEX19 (1-299) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PEX19 |
| Gene ID: |
5824 |
| Uniprot ID: |
PEX19_HUMAN |
| Immunogen Region: |
1-299 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human PEX19 (NP_002848.1). |
| Immunogen Sequence: |
MAAAEEGCSVGAEADRELEE LLESALDDFDKAKPSPAPPS TTTAPDASGPQKRSPGDTAK DALFASQEKFFQELFDSELA SQATAEFEKAMKELAEEEPH LVEQFQKLSEAAGRVGSDMT SQQEFTSCLKETLSGLAKNA TDLQNSSMSEEELTKAMEGL GMDEGDGEGNILPIMQSIMQ NLLSKDVLYPSLKEITEKYP EWLQSHRESLPPEQFEKYQE QHSVMCKICEQFEAETPTD |
| Tissue Specificity | Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. |
| Function | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. |
| Protein Name | Peroxisomal Biogenesis Factor 1933 Kda Housekeeping ProteinPeroxin-19Peroxisomal Farnesylated Protein |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | CytoplasmPeroxisome MembraneLipid-AnchorCytoplasmic SideMainly CytoplasmicSome Fraction Membrane-Associated To The Outer Surface Of Peroxisomes |
| Alternative Antibody Names | Anti-Peroxisomal Biogenesis Factor 19 antibodyAnti-33 Kda Housekeeping Protein antibodyAnti-Peroxin-19 antibodyAnti-Peroxisomal Farnesylated Protein antibodyAnti-PEX19 antibodyAnti-HK33 antibodyAnti-PXF antibodyAnti-OK antibodyAnti-SW-cl.22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and NHEJ1 knockout (KO) HeLa cells, using [KO Validated] NHEJ1 Rabbit polyclonal antibody (STJ11103937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/176582/367429/STJ11103937_1__73085.1713132967.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and NHEJ1 knockout (KO) HeLa cells, using [KO Validated] NHEJ1 Rabbit polyclonal antibody (STJ11103937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.")