| Short Description : | Rabbit polyclonal PEX14 (118-377) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PEX14 |
| Gene ID: | 5195 |
| Uniprot ID: | PEX14_HUMAN |
| Immunogen Region: | 118-377 |
| Immunogen Sequence: | GIAFGFHQLYKKYLLPLILG GREDRKQLERMEAGLSELSG SVAQTVTQLQTTLASVQELL IQQQQKIQELAHELAAAKAT TSTNWILESQNINELKSEIN SLKGLLLNRRQFPPSPSAPK IPSWQIPVKSPSPSSPAAVN HHSSSDISPVSNESTSSSPG KEGHSPEGSTVTYHLLGPQE EGEGVVDVKGQVRMEVQGEE EKREDKEDEEDEEDDDVSHV DEEDCLGVQREDRRGGDGQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-377 of human PEX14 (NP_004556.1). |
| Function | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin. |
| Protein Name | Peroxisomal Membrane Protein Pex14Pts1 Receptor-Docking ProteinPeroxin-14Peroxisomal Membrane Anchor Protein Pex14 |
| Database Links | Reactome: R-HSA-8866654Reactome: R-HSA-9033241Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Peroxisomal Membrane Protein Pex14 antibodyAnti-Pts1 Receptor-Docking Protein antibodyAnti-Peroxin-14 antibodyAnti-Peroxisomal Membrane Anchor Protein Pex14 antibodyAnti-PEX14 antibody |
Information sourced from Uniprot.org
