![Anti-Peroxiredoxin 1/PAG antibody [SM5204] (STJA0005204)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180248/403746/STJA0005204_1__44245.1738950731.png?c=1 "Anti-Peroxiredoxin 1/PAG antibody [SM5204] (STJA0005204)")
![Anti-Peroxiredoxin 1/PAG antibody [SM5204] (STJA0005204)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180248/403746/STJA0005204_1__44245.1738950731.png?c=1 "Anti-Peroxiredoxin 1/PAG antibody [SM5204] (STJA0005204)")
Anti-Peroxiredoxin 1/PAG antibody [SM5204] (STJA0005204)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse Peroxiredoxin 1
General Information
| Short Description | Mouse monoclonal anti-Peroxiredoxin 1/PAG for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5204 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H, M, R) 1:500-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Prdx1 |
| Gene ID | 18477 |
| Uniprot ID | PRDX1_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Peroxiredoxin 1 |
Additional Info
| Post Translational Modifications | Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity. Acetylation increases reducing activity and resistance to superoxidation. Deacetylated by HDAC6 which decreases reducing activity. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. |
| Protein Name | Peroxiredoxin-1Macrophage 23 Kda Stress ProteinOsteoblast-Specific Factor 3Osf-3Thioredoxin Peroxidase 2Thioredoxin-Dependent Peroxide Reductase 2Thioredoxin-Dependent Peroxiredoxin 1 |
| Database Links | Reactome: R-MMU-3299685Reactome: -MMU-5628897Reactome: -MMU-9818027 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Peroxiredoxin-1 antibodyAnti-Macrophage 23 Kda Stress Protein antibodyAnti-Osteoblast-Specific Factor 3 antibodyAnti-Osf-3 antibodyAnti-Thioredoxin Peroxidase 2 antibodyAnti-Thioredoxin-Dependent Peroxide Reductase 2 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 1 antibodyAnti-Prdx1 antibodyAnti-Msp23 antibodyAnti-Paga antibodyAnti-Tdpx2 antibody |
Information sourced from Uniprot.org