Anti-Perforin antibody [S16009A] {FITC} (STJA0004283)

SKU:
STJA0004283

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Host: Rat
Applications: ICFC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Perforin-1
Clonality: Monoclonal
Clone ID: S16009A
Conjugation: FITC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.5 mg/ml
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Prf1
Gene ID: 18646
Uniprot ID: PERF_MOUSE
Tissue Specificity Detected in cytotoxic T-lymphocytes and natural killer cells.
Post Translational Modifications N-glycosylated. The glycosylation sites are facing the interior of the pore.
Function Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently. Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu.
Protein Name Perforin-1
P1
Cytolysin
Lymphocyte Pore-Forming Protein
Cellular Localisation Cytolytic Granule
Secreted
Cell Membrane
Multi-Pass Membrane Protein
Endosome Lumen
Released From Cytotoxic Lymphocytes
Together With Proapoptotic Granzymes: Stored In Cytolytic Granules Of Cytolytic T-Lymphocytes And Secreted Into The Cleft Between T-Lymphocyte And Target Cell
May Be Taken Up Via Endocytosis Involving Clathrin-Coated Vesicles And Accumulate In A First Time In Large Early Endosomes
Inserts Into The Cell Membrane Of Target Cells And Forms Pores
Membrane Insertion And Pore Formation Requires A Major Conformation Change
Alternative Antibody Names Anti-Perforin-1 antibody
Anti-P1 antibody
Anti-Cytolysin antibody
Anti-Lymphocyte Pore-Forming Protein antibody
Anti-Prf1 antibody
Anti-Pfp antibody

Information sourced from Uniprot.org

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