| Host: |
Mouse |
| Applications: |
IHC-F/IHC-P/WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Pepsinogen I is suitable for use in Immunohistochemistry, Western Blot and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
4C6.1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 1% BSA & 0.09% sodium azide |
| Concentration: |
100 ug/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Immunogen: |
Pepsinogen I purified from human tissue |
| Background | The antibody is specific to human pepsinogen I and has no crossreactivity to human pepsinogen II. Pepsinogen I is a group of precursor molecules for pepsin. These proteins are solely synthetized and secreted into gastric lumen by chief (pepsin) cells and mucous neck cells in the gastric corpus (oxyntic mucosa). In atrophic corpus gastritis these cells disappear resulting in a decrease of the serum level of pepsinogen I and in a reduction of the number of pepsinogen I positive cells in gastric biopsies. The presence of positive immunostaining for pepsinogen I is a highly reliable sign for the acid-secreting oxyntic glands. In gastric heterotopia of the duodenal bulb, but not in gastric metaplasia, the oxyntic-type glands give a positive immunohistochemical reaction for pepsinogen I. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
