| Post Translational Modifications | Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. Met-enkephalin: Processed and degraded by ACE. Leu-enkephalin: Processed and degraded by ACE. Met-enkephalin-Arg-Gly-Leu: Probably cleaved by ACE. Met-enkephalin-Arg-Phe: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
| Function | Met-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leu-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Met-enkephalin-Arg-Phe: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. PENK(114-133): Increases glutamate release in the striatum and decreases GABA concentration in the striatum. PENK(237-258): Increases glutamate release in the striatum. |
| Protein Name | Proenkephalin-A Cleaved Into - Synenkephalin - Met-EnkephalinOpioid Growth FactorOgf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-381426Reactome: R-HSA-418594Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecreted |
| Alternative Antibody Names | Anti-Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin antibodyAnti-Opioid Growth Factor antibodyAnti-Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe antibodyAnti-PENK antibody |
Information sourced from Uniprot.org
