| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Rat/Mouse/Marmoset |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pejvakin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Pjvk |
| Gene ID: |
381375 |
| Uniprot ID: |
PJVK_MOUSE |
| Specificity: |
Specific for Pejvakin. |
| Immunogen: |
A synthetic peptide from mouse Pejvakin conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat. |
| Function | Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. |
| Protein Name | PejvakinProtein Sirtaki |
| Cellular Localisation | Peroxisome MembraneCell ProjectionCiliumAssociates With The Peroxisomal MembraneIt Is Unclear Whether It Is Embedded Or Just Associated With The Peroxisomal MembraneLocalizes To Ciliary Rootlet |
| Alternative Antibody Names | Anti-Pejvakin antibodyAnti-Protein Sirtaki antibodyAnti-Pjvk antibodyAnti-Dfnb59 antibodyAnti-Gm1001 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
