| Post Translational Modifications | Phosphorylated in the intracellular domain on tyrosine residues. Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2. Phosphorylated when in the presence of SVEP1. |
| Function | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis. |
| Protein Name | Platelet Endothelial Aggregation Receptor 1Hpear1Multiple Epidermal Growth Factor-Like Domains Protein 12Multiple Egf-Like Domains Protein 12 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCell ProjectionLamellipodiumDetected On The Cell Surface In Resting Platelets |
| Alternative Antibody Names | Anti-Platelet Endothelial Aggregation Receptor 1 antibodyAnti-Hpear1 antibodyAnti-Multiple Epidermal Growth Factor-Like Domains Protein 12 antibodyAnti-Multiple Egf-Like Domains Protein 12 antibodyAnti-PEAR1 antibodyAnti-MEGF12 antibody |
Information sourced from Uniprot.org
