| Tissue Specificity | Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas. |
| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3Nherf-3Cftr-Associated Protein Of 70 KdaNa(+/H(+ Exchanger Regulatory Factor 3Na/Pi Cotransporter C-Terminal-Associated Protein 1Napi-Cap1Pdz Domain-Containing Protein 1Sodium-Hydrogen Exchanger Regulatory Factor 3 |
| Database Links | |
| Cellular Localisation | MembranePeripheral Membrane ProteinCell MembraneAssociated With Peripheral MembranesLocalizes To The Apical Compartment Of Proximal Tubular Cells And To Sinusoidal Liver Membranes |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3 antibodyAnti-Nherf-3 antibodyAnti-Cftr-Associated Protein Of 70 Kda antibodyAnti-Na(+/H(+ Exchanger Regulatory Factor 3 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 1 antibodyAnti-Napi-Cap1 antibodyAnti-Pdz Domain-Containing Protein 1 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 3 antibodyAnti-PDZK1 antibodyAnti-CAP70 antibodyAnti-NHERF3 antibodyAnti-PDZD1 antibody |
Information sourced from Uniprot.org
