| Tissue Specificity | Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. |
| Post Translational Modifications | Phosphorylation at Ser-395 negatively regulates its interaction with SLC26A3. |
| Function | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf4Nherf-4Intestinal And Kidney-Enriched Pdz ProteinNatrium-Phosphate Cotransporter Iia C-Terminal-Associated Protein 2Na/Pi Cotransporter C-Terminal-Associated Protein 2Napi-Cap2Pdz Domain-Containing Protein 2Pdz Domain-Containing Protein 3Sodium-Hydrogen Exchanger Regulatory Factor 4 |
| Database Links | Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmPreferentially Accumulates At The Apical Surface And Ileal Brush Border Of Intestinal Epithelial Cells |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf4 antibodyAnti-Nherf-4 antibodyAnti-Intestinal And Kidney-Enriched Pdz Protein antibodyAnti-Natrium-Phosphate Cotransporter Iia C-Terminal-Associated Protein 2 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 2 antibodyAnti-Napi-Cap2 antibodyAnti-Pdz Domain-Containing Protein 2 antibodyAnti-Pdz Domain-Containing Protein 3 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 4 antibodyAnti-NHERF4 antibodyAnti-IKEPP antibodyAnti-PDZD3 antibodyAnti-PDZK2 antibodyAnti-DLNB27 antibody |
Information sourced from Uniprot.org
