| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDZD3 (1-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NHERF4 |
| Gene ID: |
79849 |
| Uniprot ID: |
NHRF4_HUMAN |
| Immunogen Region: |
1-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human PDZD3 (NP_079067.3). |
| Immunogen Sequence: |
MEKAADLQDTASLTLKFKFN PKLGIDNPVLSLAEDHDPYD PWSLERPRFCLLSKEEGKSF GFHLQQELGRAGHVVCRVDP GTSAQRQGLQEGDRILAVNN DVVEHEDYAVVVRRIRASSP RVLLTVLARHAHDVARAQLG EDAHLCPTLGPGVRPRLCHI VKDEGGFGFSVTHGNQGPFW |
| Tissue Specificity | Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. |
| Post Translational Modifications | Phosphorylation at Ser-395 negatively regulates its interaction with SLC26A3. |
| Function | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf4Nherf-4Intestinal And Kidney-Enriched Pdz ProteinNatrium-Phosphate Cotransporter Iia C-Terminal-Associated Protein 2Na/Pi Cotransporter C-Terminal-Associated Protein 2Napi-Cap2Pdz Domain-Containing Protein 2Pdz Domain-Containing Protein 3Sodium-Hydrogen Exchanger Regulatory Factor 4 |
| Database Links | Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmPreferentially Accumulates At The Apical Surface And Ileal Brush Border Of Intestinal Epithelial Cells |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf4 antibodyAnti-Nherf-4 antibodyAnti-Intestinal And Kidney-Enriched Pdz Protein antibodyAnti-Natrium-Phosphate Cotransporter Iia C-Terminal-Associated Protein 2 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 2 antibodyAnti-Napi-Cap2 antibodyAnti-Pdz Domain-Containing Protein 2 antibodyAnti-Pdz Domain-Containing Protein 3 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 4 antibodyAnti-NHERF4 antibodyAnti-IKEPP antibodyAnti-PDZD3 antibodyAnti-PDZK2 antibodyAnti-DLNB27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
