| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDX1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDX1 |
| Gene ID: |
3651 |
| Uniprot ID: |
PDX1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1 (NP_000200.1). |
| Immunogen Sequence: |
MNGEEQYYAATQLYKDPCAF QRGPAPEFSASPPACLYMGR QPPPPPPHPFPGALGALEQG SPPDISPYEVPPLADDPAVA HLHHHLPAQLALPHPPAGPF |
| Tissue Specificity | Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). |
| Post Translational Modifications | Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol. |
| Function | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer.the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-CTTAATTG-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| Protein Name | Pancreas/Duodenum Homeobox Protein 1Pdx-1Glucose-Sensitive FactorGsfInsulin Promoter Factor 1Ipf-1Insulin Upstream Factor 1Iuf-1Islet/Duodenum Homeobox-1Idx-1Somatostatin-Transactivating Factor 1Stf-1 |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-210747 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Pancreas/Duodenum Homeobox Protein 1 antibodyAnti-Pdx-1 antibodyAnti-Glucose-Sensitive Factor antibodyAnti-Gsf antibodyAnti-Insulin Promoter Factor 1 antibodyAnti-Ipf-1 antibodyAnti-Insulin Upstream Factor 1 antibodyAnti-Iuf-1 antibodyAnti-Islet/Duodenum Homeobox-1 antibodyAnti-Idx-1 antibodyAnti-Somatostatin-Transactivating Factor 1 antibodyAnti-Stf-1 antibodyAnti-PDX1 antibodyAnti-IPF1 antibodyAnti-STF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
