Anti-PDK3 antibody (170-250 aa) (STJ191232)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 170-250
General Information
| Short Description | Rabbit polyclonal anti-Pyruvate dehydrogenase kinase isozyme 3, mitochondrial (170-250 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDK3 |
| Gene ID | 5165 |
| Uniprot ID | PDK3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 170-250 |
| Immunogen Region | 170-250 aa |
| Specificity | PDK3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. |
| Protein Name | Pyruvate DehydrogenaseAcetyl-Transferring Kinase Isozyme 3 - MitochondrialPyruvate Dehydrogenase Kinase Isoform 3 |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Pyruvate Dehydrogenase antibodyAnti-Acetyl-Transferring Kinase Isozyme 3 - Mitochondrial antibodyAnti-Pyruvate Dehydrogenase Kinase Isoform 3 antibodyAnti-PDK3 antibodyAnti-PDHK3 antibody |
Information sourced from Uniprot.org