| Tissue Specificity | Detected in the flagellum and head region of spermatozoa (at protein level). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level). |
| Post Translational Modifications | Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Phosphorylated. |
| Function | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. |
| Protein Name | Protein Disulfide-Isomerase A358 Kda Glucose-Regulated Protein58 Kda Microsomal ProteinP58Disulfide Isomerase Er-60Endoplasmic Reticulum Resident Protein 57Er Protein 57Erp57Endoplasmic Reticulum Resident Protein 60Er Protein 60Erp60 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-901042Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic ReticulumEndoplasmic Reticulum LumenMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Protein Disulfide-Isomerase A3 antibodyAnti-58 Kda Glucose-Regulated Protein antibodyAnti-58 Kda Microsomal Protein antibodyAnti-P58 antibodyAnti-Disulfide Isomerase Er-60 antibodyAnti-Endoplasmic Reticulum Resident Protein 57 antibodyAnti-Er Protein 57 antibodyAnti-Erp57 antibodyAnti-Endoplasmic Reticulum Resident Protein 60 antibodyAnti-Er Protein 60 antibodyAnti-Erp60 antibodyAnti-PDIA3 antibodyAnti-ERP57 antibodyAnti-ERP60 antibodyAnti-GRP58 antibody |
Information sourced from Uniprot.org
