Anti-PDE9A antibody {FITC} (STJ502391)

SKU:
STJ502391-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE9A is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55 µg/µl
Dilution Range: WB: 1:500
DB: 1:100
ELISA: 1:100
IP: 1:250
IHC: 1:100
ICC: 1:100
IF: 1:100
CFM: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE9A
Gene ID: 5152
Uniprot ID: PDE9A_HUMAN
Specificity: Does not cross-react with PDE9B protein or any other PDE family members.
Immunogen: Synthetic cyclic peptide common to all PDE9A variants
Tissue Specificity Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. In brain, present in the cortex, cerebellum, and subiculum (at protein level). In heart, primarily localizes to myocytes.
Function Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
Protein Name High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a
Database Links Reactome: R-HSA-418457
Cellular Localisation Isoform Pde9a1: Cell Projection
Ruffle Membrane
Cytoplasm
Perinuclear Region
Golgi Apparatus
Endoplasmic Reticulum
Cell Membrane
Sarcolemma
Isoform Pde9a2: Cell Projection
Isoform Pde9a3: Cytoplasm
Isoform Pde9a17: Cytoplasm
Alternative Antibody Names Anti-High Affinity Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase 9a antibody
Anti-PDE9A antibody

Information sourced from Uniprot.org

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