| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-High affinity cAMP-specific and IBMX-insensitive 3 NA, 5 cyclic phosphodiesterase 8A is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE8A |
| Gene ID: | 5151 |
| Uniprot ID: | PDE8A_HUMAN |
| Specificity: | This antibody detects endogenous levels of PDE8A at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human PDE8A |
| Post Translational Modifications | Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. |
| Protein Name | High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a |
| Database Links | Reactome: R-HSA-418555 |
| Alternative Antibody Names | Anti-High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a antibodyAnti-PDE8A antibody |
Information sourced from Uniprot.org