| Tissue Specificity | Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. |
| Post Translational Modifications | Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. |
| Protein Name | High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a |
| Database Links | Reactome: R-HSA-418555 |
| Alternative Antibody Names | Anti-High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8a antibodyAnti-PDE8A antibody |
Information sourced from Uniprot.org
