Anti-PDE6D antibody (1-150) (STJ116962)

Name: Anti-PDE6D antibody (1-150) (STJ116962)
SKU: STJ116962
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ116962

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Short Description	Rabbit polyclonal PDE6D (1-150) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PDE6D
Gene ID	5147
Uniprot ID	PDE6D_HUMAN
Immunogen Region	1-150
Immunogen Sequence	MSAKDERAREILRGFKLNWM NLRDAETGKILWQGTEDLSV PGVEHEARVPKKILKCKAVS RELNFSSTEQMEKFRLEQKV YFKGQCLEEWFFEFGFVIPN STNTWQSLIEAAPESQMMPA SVLTGNVIIETKFFDDDLLV STSRVRLFYV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE6D (NP_002592.1).

Tissue Specificity	Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.
Function	Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Required for RAB28 localization to the cone cell outer segments in the retina. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
Protein Name	Retinal Rod Rhodopsin-Sensitive Cgmp 3' -5'-Cyclic Phosphodiesterase Subunit Delta Gmp-Pde Delta Protein P17
Database Links	Reactome: R-HSA-5624958 Reactome: R-HSA-9648002
Cellular Localisation	Cytoplasm Cytosol Cytoplasmic Vesicle Membrane Peripheral Membrane Protein Cytoskeleton Cilium Basal Body
Alternative Antibody Names	Anti-Retinal Rod Rhodopsin-Sensitive Cgmp 3' -5'-Cyclic Phosphodiesterase Subunit Delta antibody Anti-Gmp-Pde Delta antibody Anti-Protein P17 antibody Anti-PDE6D antibody Anti-PDED antibody

Information sourced from Uniprot.org