| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE5A |
| Gene ID: | 8654 |
| Uniprot ID: | PDE5A_HUMAN |
| Immunogen Region: | 1-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE5A (NP_001074.2). |
| Immunogen Sequence: | MERAGPSFGQQRQQQQPQQQ KQQQRDQDSVEAWLDDHWDF TFSYFVRKATREMVNAWFAE RVHTIPVCKEGIRGHTESCS CPLQQSPRADNSAPGTPTRK ISASEFDRPLRPIVVKDSEG TVSFLSDSEKKEQMPLTPPR FDHDEGDQCS |
| Tissue Specificity | Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Protein Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Alternative Antibody Names | Anti-Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase antibodyAnti-Cgmp-Binding Cgmp-Specific Phosphodiesterase antibodyAnti-Cgb-Pde antibodyAnti-PDE5A antibodyAnti-PDE5 antibody |
Information sourced from Uniprot.org