| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Chicken/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE4D7 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.2 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Pde4d |
| Gene ID: |
238871 |
| Uniprot ID: |
PDE4D_MOUSE |
| Specificity: |
Does not crossDoes not cross react with other PDE family members including PDE4A, PDE4B or PDE4C. |
| Immunogen: |
Synthetic peptide corresponding to unique amino acid sequence on PDE4D7 variant. |
| Tissue Specificity | Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis. |
| Post Translational Modifications | Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
| Protein Name | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4dDpde3 |
| Database Links | Reactome: R-MMU-180024Reactome: -MMU-418555 |
| Cellular Localisation | CytoplasmMembraneCytoskeletonMicrotubule Organizing CenterCentrosomeApical Cell MembraneColocalized With Shank2 To The Apical Membrane Of Colonic Crypt CellsFound In The Soluble FractionAssociated With MembranesAnd Associated With The Cytoskeleton And The Centrosome |
| Alternative Antibody Names | Anti-Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d antibodyAnti-Dpde3 antibodyAnti-Pde4d antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
