| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cGMP-inhibited 3 NA, 5 cyclic phosphodiesterase 3B is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE3B |
| Gene ID: |
5140 |
| Uniprot ID: |
PDE3B_HUMAN |
| Specificity: |
PDE3B Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B |
| Database Links | Reactome: R-HSA-165160Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibodyAnti-Cgipde1 antibodyAnti-Cgip1 antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase B antibodyAnti-Cgi-Pde B antibodyAnti-PDE3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
