• Western blot with Anti-PDE3A Antibody (STJ502263) with PD3A peptide. Antibody at 1:250 dilution in buffer.

Anti-PDE3A antibody (STJ502263)

SKU:
STJ502263-100

£481.50
Shipping:
Free Shipping
Current Stock:
Host: Goat
Applications: ELISA/IP/WB
Reactivity: Human/Monkey/Mouse/Rat/Xenopus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-PDE3A is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE3A
Gene ID: 5139
Uniprot ID: PDE3A_HUMAN
Immunogen: Synthetic peptide selective only for PDE3A variants
Function Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Protein Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a
Cyclic Gmp-Inhibited Phosphodiesterase A
Cgi-Pde A
Cgmp-Inhibited Camp Phosphodiesterase
Cgi-Pde
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cytoplasm
Cytosol
Alternative Antibody Names Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibody
Anti-Cyclic Gmp-Inhibited Phosphodiesterase A antibody
Anti-Cgi-Pde A antibody
Anti-Cgmp-Inhibited Camp Phosphodiesterase antibody
Anti-Cgi-Pde antibody
Anti-PDE3A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance