Anti-PDE12 antibody (570-620) {FITC} (STJ502225)

SKU:
STJ502225-100

£546.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE12 (570-620) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE12
Gene ID: 201626
Uniprot ID: PDE12_HUMAN
Immunogen Region: 570-620
Immunogen: Synthetic peptide taken within amino acid region 570-620 on human PDE12 protein.
Tissue Specificity Ubiquitous.
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.
Protein Name 2' -5'-Phosphodiesterase 12
2'-Pde
2-Pde
Mitochondrial Deadenylase
Database Links Reactome: R-HSA-8983711
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-2' -5'-Phosphodiesterase 12 antibody
Anti-2'-Pde antibody
Anti-2-Pde antibody
Anti-Mitochondrial Deadenylase antibody
Anti-PDE12 antibody

Information sourced from Uniprot.org

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